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Relationships between brain structure-function coupling in normal aging and cognition: A cross-ethnicity
Chang Liu1, Jing Jing2, Jiyang Jiang3
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Neuroimage
|September 12, 2024
Summary
Brain structure-function coupling weakens with age, impacting cognitive function. This study introduces a new index to measure this coupling, offering insights into aging brain mechanisms and potential early diagnosis for neurological diseases.
Area of Science:
- Neuroscience
- Brain Imaging
- Cognitive Aging
Background:
- Understanding how brain structure and function interact is crucial for explaining cognitive behaviors.
- The precise nature of structure-function coupling in aging brains remains largely unknown.
Purpose of the Study:
- To develop and validate a novel index, the Coupling in Brain Structural connectome and Functional connectome (C-BSF) index.
- To quantify regional structure-function coupling in aging individuals.
- To investigate the relationship between structure-function coupling, age, and cognitive performance.
Main Methods:
- Utilized diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) data.
- Analyzed data from two large cohorts: the PRECISE study (n=2007) and the MAS cohort (n=254).
- Calculated the C-BSF index to assess structure-function coupling across different brain networks.
Main Results:
- Structure-function coupling varied across brain networks, being strongest in the visual network and weakest in the ventral attention network.
- Weaker structure-function coupling correlated with advanced age and poorer cognitive status.
- Reduced coupling in the visual network was linked to visuospatial performance and partially explained the effect of age on visuospatial function.
Conclusions:
- The C-BSF index provides a valuable measure for assessing brain structure-function integrity in aging.
- Aging is associated with diminished brain structure-function coupling, contributing to cognitive decline.
- Findings may inform early diagnostic and therapeutic strategies for age-related neurological conditions.
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