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Related Experiment Video

Updated: Jun 13, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Relationships between brain structure-function coupling in normal aging and cognition: A cross-ethnicity

Chang Liu1, Jing Jing2, Jiyang Jiang3

  • 1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Neuroimage
|September 12, 2024
PubMed
Summary
This summary is machine-generated.

Brain structure-function coupling weakens with age, impacting cognitive function. This study introduces a new index to measure this coupling, offering insights into aging brain mechanisms and potential early diagnosis for neurological diseases.

Keywords:
Brain mechanismsCognitionStructure-function coupling

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Cognitive Aging

Background:

  • Understanding how brain structure and function interact is crucial for explaining cognitive behaviors.
  • The precise nature of structure-function coupling in aging brains remains largely unknown.

Purpose of the Study:

  • To develop and validate a novel index, the Coupling in Brain Structural connectome and Functional connectome (C-BSF) index.
  • To quantify regional structure-function coupling in aging individuals.
  • To investigate the relationship between structure-function coupling, age, and cognitive performance.

Main Methods:

  • Utilized diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) data.
  • Analyzed data from two large cohorts: the PRECISE study (n=2007) and the MAS cohort (n=254).
  • Calculated the C-BSF index to assess structure-function coupling across different brain networks.

Main Results:

  • Structure-function coupling varied across brain networks, being strongest in the visual network and weakest in the ventral attention network.
  • Weaker structure-function coupling correlated with advanced age and poorer cognitive status.
  • Reduced coupling in the visual network was linked to visuospatial performance and partially explained the effect of age on visuospatial function.

Conclusions:

  • The C-BSF index provides a valuable measure for assessing brain structure-function integrity in aging.
  • Aging is associated with diminished brain structure-function coupling, contributing to cognitive decline.
  • Findings may inform early diagnostic and therapeutic strategies for age-related neurological conditions.