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Updated: Jun 13, 2025

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Abamectin at environmentally relevant concentrations impairs bone development in zebrafish larvae.

Yuting Wang1, Jiawen He2, Min Li1

  • 1College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
|September 12, 2024
PubMed
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Abamectin pesticide exposure negatively impacts zebrafish bone development, causing deformities and delayed mineralization. This study reveals molecular mechanisms of abamectin toxicity on cartilage and bone formation in early life stages.

Area of Science:

  • Environmental Toxicology
  • Developmental Biology
  • Ecotoxicology

Background:

  • Abamectin (ABM) is a widely used pesticide with known neurological effects on pests.
  • Widespread agricultural use leads to environmental contamination, particularly in water bodies.
  • ABM's impact on non-target organism development is documented, but bone development effects are understudied.

Purpose of the Study:

  • To investigate the effects of environmentally relevant abamectin concentrations on early bone development in zebrafish.
  • To identify molecular mechanisms underlying abamectin's impact on cartilage and bone formation.

Main Methods:

  • Zebrafish larvae were exposed to varying concentrations of abamectin (1, 5, 25 μg/L).
  • Skeletal morphology, including cartilage and bone development, was assessed.
Keywords:
AbamectinBone developmentBone mineralizationToxic effectZebrafish

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  • Apoptosis rates, mortality, and gene expression related to bone development were analyzed using quantitative PCR.

    • Main Results:

    • Abamectin exposure caused significant cartilage and bone deformities in zebrafish larvae.
    • Dose-dependent increases in deformity, mortality, and apoptosis were observed.
    • Abamectin delayed bone mineralization even at low concentrations and altered gene expression related to skeletal development.

    Conclusions:

    • Abamectin significantly disrupts early bone and cartilage development in zebrafish.
    • Observed skeletal deformities and delayed mineralization highlight abamectin's developmental toxicity.
    • This study provides crucial insights into the molecular mechanisms of abamectin's skeletal toxicity in aquatic vertebrates.