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Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Recognising angiosarcoma presenting as an enlarging ecchymotic plaque.

Michelle Wu¹, Theone Papps^2,3, Bruno Blaya-Alvarez^4,2

¹Department of Dermatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia michelle.wu@health.nsw.gov.au.

BMJ Case Reports

|September 12, 2024

Summary

Cutaneous angiosarcoma (cAS) is a rare vascular cancer often mistaken for a bruise. Early biopsy is crucial for diagnosing this aggressive cancer, improving patient outcomes.

Keywords:

Dermatology Skin cancer

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Area of Science:

Oncology
Dermatopathology

Background:

Cutaneous angiosarcoma (cAS) is a rare vascular malignancy with poor prognosis.
Diagnosis is often delayed due to its subtle, bruise-like presentation.
Low index of suspicion contributes to diagnostic delays.

Observation:

A case of a male patient presenting with an ecchymotic plaque on the forehead is described.
The lesion was initially misdiagnosed as benign.
Over six weeks, the lesion enlarged and ulcerated.

Findings:

Biopsy confirmed the diagnosis of cutaneous angiosarcoma.
This case highlights the diagnostic challenges of cAS.

Implications:

Physicians should maintain a high index of suspicion for cAS.
A low threshold for biopsy is recommended for suspicious atraumatic ecchymotic lesions.
Prompt diagnosis and treatment are vital for improving cAS prognosis.