Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CRISPR01:59

CRISPR

49.8K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
49.8K
CRISPR and crRNAs02:53

CRISPR and crRNAs

16.9K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
16.9K
Homologous Recombination02:31

Homologous Recombination

50.3K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
50.3K
Autoimmune Disorders01:29

Autoimmune Disorders

396
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
396

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation and characterization of mesenchymal stem cells from caprine umbilical cord tissue matrix.

Tissue & cell·2016
Same author

Secretome Cues Modulate the Neurogenic Potential of Bone Marrow and Dental Stem Cells.

Molecular neurobiology·2016
Same author

Long-circulatory nanoparticles for gemcitabine delivery: Development and investigation of pharmacokinetics and in-vivo anticancer efficacy.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2016
Same author

Influence of immobilization and forced swim stress on the neurotoxicity of lambda-cyhalothrin in rats: Effect on brain biogenic amines and BBB permeability.

Neurotoxicology·2016
Same author

Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cells.

Chemico-biological interactions·2016
Same author

Pragmatic use of insulin degludec/insulin aspart co-formulation: A multinational consensus statement.

Indian journal of endocrinology and metabolism·2016

Related Experiment Video

Updated: Jun 13, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.8K

Current progress in CRISPR-Cas systems for autoimmune diseases.

Juveriya Israr1, Ajay Kumar2

  • 1Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Lucknow, Barabanki, Uttar Pradesh, India.

Progress in Molecular Biology and Translational Science
|September 12, 2024
PubMed
Summary
This summary is machine-generated.

CRISPR gene editing offers a promising new avenue for treating autoimmune diseases by precisely modifying immune pathways to reduce harmful responses and potentially cure genetic disorders, improving patient outcomes.

Keywords:
Autoimmune diseasesCRISPR-Cas systemsGene editingGenome editingImmune regulationPersonalized treatmentPrecision medicineTherapeutic applications

More Related Videos

Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice
09:00

Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice

Published on: August 2, 2018

8.1K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

57

Related Experiment Videos

Last Updated: Jun 13, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.8K
Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice
09:00

Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice

Published on: August 2, 2018

8.1K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

57

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Autoimmune diseases affect millions, causing significant health burdens and impacting well-being.
  • Current treatments for autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and type 1 diabetes aim to manage symptoms by altering immune responses.
  • There is a critical need for enhanced knowledge, research, and support for individuals with autoimmune conditions.

Purpose of the Study:

  • To explore the potential of CRISPR gene editing as a therapeutic strategy for autoimmune diseases.
  • To investigate how CRISPR-Cas9 technology can be utilized to modify immune pathways and correct genetic defects.
  • To assess the safety, efficacy, and targeted delivery of CRISPR-based therapies for autoimmune conditions.

Main Methods:

  • CRISPR-Cas9 gene editing technology utilizes guide RNA and enzymatic pathways for precise DNA modification.
  • Application of CRISPR to alter specific genetic or immune mechanisms involved in autoimmune diseases.
  • Development of improved delivery techniques and kits for safer and more effective CRISPR-mediated interventions.

Main Results:

  • CRISPR gene editing shows promise in alleviating autoimmune disease symptoms by promoting immune tolerance and reducing reactivity.
  • Preclinical and early clinical studies indicate potential for CRISPR-engineered therapies to treat conditions like rheumatoid arthritis, multiple sclerosis, and type 1 diabetes.
  • Advancements in CRISPR technology have led to safer, more effective, and accurately targeted therapeutic approaches.

Conclusions:

  • CRISPR gene editing represents a revolutionary approach for developing cures and personalized therapies for autoimmune diseases.
  • Precise CRISPR editing can correct genetic disorders underlying autoimmune conditions and modify effector cells to decrease autoimmune reactions.
  • Ongoing research and technological improvements in CRISPR delivery systems are paving the way for advanced treatments with reduced side effects.