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Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
[Research advances in mechanistic signaling in pulmonary fibrosis]
1School of Public Health, Nanjing Medical University, Pulmonary and Critical Care Medicine, Chongqing Prevention and Treatment Center for Occupational Disease, Chongqing 400060, China.
Abstract:
Pulmonary fibrosis is a complex and intractable disease characterized by extracellular matrix accumulation and altered mechanical properties of lung tissue. Biomechanical properties are closely related to the development, progression, and treatment of tissue fibrosis. In this review, we summarized the changes in the pulmonary biomechanical microenvironment, highlight the role of mechanotransduction in pulmonary fibrosis, and describe recent clinical advances targeting mechanical signals to alleviate pulmonary fibrosis.
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