Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.

Advanced healthcare materials·2026
Same author

Untethered thin-film neurostimulator wrapped around tiny nerve trunks for wireless neuromodulation.

Science advances·2026
Same author

Neuroimmune-Metabolic Regulation by a Wireless Biodegradable Neuromodulator for Cardiovascular Therapy in a Mouse Model.

ACS nano·2026
Same author

Hydrogel-based wearable and implantable biosensors in health monitoring.

Biomaterials science·2026
Same author

Injectable hydrogel bioelectrostimulator for wireless deep brain neuromodulation.

Nature communications·2026
Same author

Chronic neurostimulation of splenic nerve enabled by hydrogel-bioelectronics for wireless electroceutical immunomodulation therapy.

National science review·2026

Related Experiment Video

Updated: Jun 13, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

7.8K

Highly-stable, injectable, conductive hydrogel for chronic neuromodulation.

Ming Yang1, Lufang Wang2, Wenliang Liu1

  • 1National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Nature Communications
|September 12, 2024
PubMed
Summary

Researchers developed an injectable hydrogel bioelectronic device for precise nerve stimulation. This stable and conductive interface offers a new approach for treating diseases by targeting delicate peripheral nerves.

More Related Videos

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.3K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.8K

Related Experiment Videos

Last Updated: Jun 13, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

7.8K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.3K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.8K

Area of Science:

  • Bioelectronic Medicine
  • Materials Science
  • Neuroscience

Background:

  • Electroceuticals offer promising treatments for refractory diseases by modulating peripheral nerves.
  • Challenges exist in stabilizing neural electrodes for delicate peripheral nerves due to their small size and fragility.

Purpose of the Study:

  • To develop a robust neural interface for fine peripheral nerves using injectable bio-adhesive hydrogel bioelectronics.
  • To optimize hydrogel properties for enhanced injectability, conductivity, and stability.

Main Methods:

  • Incorporation of a multifunctional molecular regulator during hydrogel network formation.
  • Fine-tuning reaction kinetics and multi-scale interactions to optimize hydrogel properties.
  • Evaluation of chronic vagus neuromodulation for myocardial infarction therapy in a male rat model.

Main Results:

  • Achieved optimized injectability and conductivity of the hydrogel.
  • Ensured mechanical and electrical stability without compromising injectability.
  • Demonstrated minimal tissue damage and low, stable impedance for chronic neuromodulation.

Conclusions:

  • The developed injectable hydrogel bioelectronics provide a stable and conductive interface for targeting challenging peripheral nerves.
  • This technology facilitates precision bioelectronic medicine and offers potential for treating various refractory diseases.