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Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
Published on: September 22, 2023
The role of gut-derived short-chain fatty acids in Parkinson's disease
Mohamed J Saadh1, Anfal Nabeel Mustafa2, Mohammed Ahmed Mustafa3,4
1Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan. mohamedjsaadh@gmail.com.
Abstract:
The emerging function of short-chain fatty acids (SCFAs) in Parkinson's disease (PD) has been investigated in this article. SCFAs, which are generated via the fermentation of dietary fiber by gut microbiota, have been associated with dysfunction of the gut-brain axis and, neuroinflammation. These processes are integral to the development of PD. This article examines the potential therapeutic implications of SCFAs in the management of PD, encompassing their capacity to modulate gastrointestinal permeability, neuroinflammation, and neuronal survival, by conducting an extensive literature review. As a whole, this article emphasizes the potential therapeutic utility of SCFAs as targets for the management and treatment of PD.
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