Related Experiment Video
Updated: Jun 13, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Retraction: SSRP1 Promotes Colorectal Cancer Progression and is Negatively Regulated by miR-28-5p
Abstract:
Retraction: Wu W, He K, Guo Q, et al. SSRP1 Promotes Colorectal Cancer Progression and is Negatively Regulated by miR-28-5p. J Cell Mol Med. 2019;23(5): 3118-3129. doi: 10.1111/jcmm.14134 The above article, published online on 14 February 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the Journal Editor-in-Chief, Stefan Constantinescu; The Foundation for Cellular and Molecular Medicine; and John Wiley & Sons Ltd. The retraction has been agreed due to the authors' admission that some of the images were mistakenly included in this article, with some of the data belonging to another project. Additionally, the article was submitted for publication by Wei Wu without consent from the co-author Honggang Yu.
Insights
This study on colorectal cancer progression has been retracted due to image duplication and unauthorized submission. The original research explored the role of SSRP1 and miR-28-5p in cancer development.
Area of Science:
- Molecular oncology
- Cancer biology
Context:
- Colorectal cancer (CRC) is a significant global health concern.
- Understanding the molecular mechanisms driving CRC progression is crucial for developing effective therapies.
Purpose:
- To investigate the role of SSRP1 in promoting colorectal cancer progression.
- To explore the regulatory relationship between SSRP1 and miR-28-5p in CRC.
Summary:
- The article investigated the role of SSRP1 in promoting colorectal cancer (CRC) progression and its regulation by miR-28-5p.
- Retraction was issued due to image duplication, data from another project being included, and submission without co-author consent.
Impact:
- This retraction highlights the importance of data integrity and ethical considerations in scientific publishing.
- It underscores the need for rigorous verification of data and proper authorship acknowledgment in research.
Related Concept Videos
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
MicroRNAs
Abnormal Proliferation
Negative Regulator Molecules
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...

