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RNF26-mediated ubiquitination of TRIM21 promotes bladder cancer progression
Dongwei Yao1,2, Feng Xin2, Xiaozhou He1
1Department of Urology, The Third Affiliated Hospital of Soochow University, Soochow University Changzhou 213000, Jiangsu, China.
American Journal of Cancer Research
|September 13, 2024
Summary
Ring finger protein 26 (RNF26) promotes bladder cancer progression by degrading TRIM21, impacting prognosis and treatment sensitivity. This RNF26/TRIM21/ZHX3 pathway is a potential therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Ring finger protein 26 (RNF26) is an E3 ubiquitin ligase implicated in poor prognosis in bladder cancer.
- The precise mechanisms of RNF26 in bladder cancer development remain unclear.
Purpose of the Study:
- To elucidate the role and underlying mechanisms of RNF26 in bladder cancer tumorigenesis.
- To identify RNF26 as a potential predictive marker and therapeutic target.
Main Methods:
- Analysis of RNF26 expression in bladder cancer tissues.
- In vitro studies involving RNF26 knockdown and overexpression in bladder cancer cell lines (UMUC3, T24).
- Investigation of the interaction between RNF26, TRIM21, and ZHX3.
Main Results:
- RNF26 expression is significantly upregulated in bladder cancer tissues and correlates with poorer prognosis.
- Higher RNF26 levels are associated with reduced immune cell infiltration and increased sensitivity to specific chemotherapies and immune checkpoint blockade.
- RNF26 knockdown inhibited bladder cancer cell growth, colony formation, and migration, while overexpression had opposite effects.
- RNF26 promotes bladder cancer progression by ubiquitinating and degrading TRIM21, leading to the regulation of downstream target ZHX3.
Conclusions:
- A novel RNF26/TRIM21/ZHX3 axis drives bladder cancer progression.
- This axis serves as a potential predictive biomarker for treatment efficacy and a therapeutic target for bladder cancer.
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