Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

396
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
396
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Pedigree Analysis01:35

Pedigree Analysis

84.1K
Overview
84.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LTF promotes central nervous system leukemia progression via neutrophil serine proteases.

Frontiers in pharmacology·2026
Same author

Changes in ovarian reserve function after laparoscopic ovarian cystectomy: a retrospective cohort study.

Frontiers in surgery·2026
Same author

Comparative efficacy of double and triple arthrodesis in adult-acquired flatfoot deformity: a retrospective analysis.

BMC surgery·2026
Same author

High Tree Species Diversity Promotes Thermal Enhancement Response of Microbial Carbon Use Efficiency.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A Hydrogel Delivery System Based on Selenium Nanoparticles and bFGF for Promoting the Repair of Skin Wounds.

Biomedicines·2026
Same author

Sex and social group altered the gut microbiome and fecal metabolome in the critically endangered Yangtze finless porpoise (<i>Neophocaena asiaeorientalis asiaeorientalis</i>).

Current zoology·2026

Related Experiment Video

Updated: Jun 13, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K

Postpartum depression and autoimmune disease: a bidirectional Mendelian randomization study.

Wenlong Yu1,2, Bingxue Su1,2, Chaoqun Wang1,2

  • 1School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, China.

Frontiers in Psychiatry
|September 13, 2024
PubMed
Summary

Postpartum depression (PPD) increases the risk of developing autoimmune diseases like type 1 diabetes and Hashimoto's thyroiditis. Autoimmune diseases do not appear to increase the risk of PPD, suggesting PPD is a causal factor.

Keywords:
Mendelian randomizationautoimmune diseaseetiologygenetic causepostpartum depression

More Related Videos

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.0K
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.3K

Related Experiment Videos

Last Updated: Jun 13, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.0K
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.3K

Area of Science:

  • Genetics and Immunology
  • Reproductive Health
  • Epidemiology

Background:

  • Postpartum depression (PPD) affects many women and families, with its association with autoimmune diseases (ADs) needing clarification.
  • The causal relationship between PPD and ADs is not well understood, necessitating further investigation.

Purpose of the Study:

  • To investigate the potential causal relationship between postpartum depression (PPD) and autoimmune diseases (ADs) using a Mendelian randomization (MR) approach.
  • To determine if PPD is a risk factor for ADs or vice versa.

Main Methods:

  • Utilized large-scale genome-wide association study (GWAS) data from the IEU OpenGWAS project and FinnGen databases.
  • Employed inverse variance weighting (IVW) for causal analysis, supported by weighted median, MR-Egger, MR-PRESSO, and leave-one-out sensitivity tests to ensure robustness.

Main Results:

  • Mendelian randomization analysis indicated that PPD significantly increases the risk of type 1 diabetes (OR=1.15), Hashimoto's thyroiditis (OR=1.21), and encephalitis (OR=1.66).
  • Reverse analysis found no genetic evidence that ADs increase the risk of PPD.
  • Sensitivity analyses confirmed no significant heterogeneity or horizontal pleiotropy.

Conclusions:

  • Postpartum depression (PPD) is identified as a potential causal risk factor for developing type 1 diabetes, Hashimoto's thyroiditis, and encephalitis.
  • Autoimmune diseases (ADs) do not appear to be a risk factor for PPD.
  • Findings offer new perspectives for PPD patient-centered prevention and intervention strategies for associated ADs.