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Facial Skin Manifestation of a Destructive, Nonkeratinizing Squamous Cell Carcinoma

Vixey Silva1, Richard G Bindernagel1, Melissa Cheng2

  • 1Dermatology, HCA Healthcare/University of South Florida (USF) Morsani College of Medicine: Largo Medical Center Program, Largo, USA.

Cureus
|September 13, 2024
PubMed

Insights

This case study highlights an unusual facial skin extension of nonkeratinizing squamous cell carcinoma (NKSCC) of the sinonasal tract. Early dermatological diagnosis and multidisciplinary care are crucial for this rare, aggressive cancer.

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Nonkeratinizing squamous cell carcinoma (NKSCC) of the sinonasal tract is a rare malignancy.
  • Cutaneous extension of sinonasal NKSCC is infrequent.
  • Elderly patients often present with multiple comorbidities.

Observation:

  • An elderly male with multiple comorbidities presented with extensive facial skin involvement.
  • Biopsy confirmed nonkeratinizing squamous cell carcinoma (NKSCC) of the sinonasal tract.
  • The tumor was p16 positive, indicating a potential human papillomavirus (HPV) etiology.

Findings:

  • The case demonstrates an unusual presentation of sinonasal NKSCC with extensive facial cutaneous metastasis.
  • P16 positivity suggests an HPV-driven carcinogenesis pathway.
  • Histopathological examination and biopsy are essential for diagnosis.

Implications:

  • Dermatologists play a vital role in the early detection of destructive facial tumors.
  • NKSCC should be considered in the differential diagnosis of aggressive facial lesions.
  • Prompt multidisciplinary management is critical for optimizing outcomes in rare cancer presentations.
  • Identifying HPV-related etiology through p16 status can inform prognosis and treatment strategies.
Keywords:
aggressive destructive lesionhpv-related oropharyngeal cancernasopharyngeal biopsyp16 testingsquamous cell carcinoma

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