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Is Obstructive Sleep Apnea Associated with Higher Covid-19 Severity?
Laíla Cândida Zacarias1, Danielle Mesquita Torres2, Samir Câmara Magalhães2,3
1Graduate Program in Cardiovascular Sciences, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Sleep Science (Sao Paulo, Brazil)
|September 13, 2024
Summary
Individuals with obstructive sleep apnea (OSA) hospitalized for COVID-19 experienced more severe illness. OSA was linked to lower oxygen levels, increased need for oxygen therapy, and higher platelet and D-dimer levels, indicating greater disease severity.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) is a common sleep disorder.
- Coronavirus disease 2019 (COVID-19) is a significant global health concern.
- The relationship between OSA and COVID-19 severity requires further investigation.
Purpose of the Study:
- To examine the association between obstructive sleep apnea (OSA) and the severity of coronavirus disease 2019 (COVID-19) in hospitalized patients.
- To identify clinical and laboratory markers associated with COVID-19 severity in patients with OSA.
Main Methods:
- A cohort of twelve individuals hospitalized with COVID-19 was studied.
- Respiratory polygraphy was used to diagnose obstructive sleep apnea (OSA).
- Patients were categorized into groups with (OSA+) and without (OSA-) obstructive sleep apnea.
Main Results:
- The OSA+ group exhibited significantly lower peripheral oxygen saturation compared to the OSA- group (p=0.041).
- COVID-19 severity was higher in the OSA+ group (100%) versus the OSA- group (28.57%) (p=0.013).
- OSA+ patients required longer oxygen therapy (p=0.038) and had elevated platelet (p=0.008) and D-dimer levels (p=0.019).
Conclusions:
- Obstructive sleep apnea is associated with increased severity of COVID-19 in hospitalized patients.
- OSA correlates with poorer oxygenation, extended oxygen therapy needs, and heightened thrombotic markers (platelets, D-dimer).
- These findings highlight the importance of considering OSA in managing COVID-19 patients.
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