Cardiac biomarkers in COVID-19: what did we learn?
Lara Srour1, Jaafar Ismail1, Rana Zareef2
1Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Insights
Elevated cardiac biomarkers in COVID-19 patients indicate a higher risk of severe disease progression and mortality. Monitoring these markers is crucial for predicting adverse cardiovascular outcomes and guiding treatment strategies.
Area of Science:
- Cardiology
- Infectious Diseases
- Biomarkers
Background:
- COVID-19 (Coronavirus Disease 2019) presents diverse clinical symptoms, with cardiovascular complications being common, especially in those with pre-existing heart conditions.
- Cardiac biomarkers are essential tools for assessing cardiac injury, stress, and inflammation in COVID-19 patients.
Purpose of the Study:
- To review and understand the correlation between cardiac biomarkers and the clinical manifestations of COVID-19.
- To highlight the role of cardiac biomarkers in risk stratification and prognosis of COVID-19 patients.
Main Methods:
- A literature search was conducted using PubMed, Medline, and Google Scholars.
- A total of 14 studies investigating cardiac biomarkers in COVID-19 patients were reviewed.
Main Results:
- Eight studies indicated that elevated troponin levels are associated with poor COVID-19 progression.
- Six studies demonstrated a significant correlation between elevated cardiac biomarkers and increased mortality in COVID-19 patients.
Conclusions:
- Elevated cardiac biomarkers are significantly linked to adverse outcomes in COVID-19, including longer hospital stays and increased mortality.
- Biomarker levels can predict the need for life support, respiratory support, and the development of myocarditis.
Objectives:
COVID-19, caused by the SARS-CoV-2 virus, has generated a global pandemic with a wide range of clinical manifestations. Cardiovascular complications are frequently observed in individuals with COVID-19, particularly those with preexisting cardiovascular risk factors or diseases. Cardiac biomarkers, including troponin, natriuretic peptides, and inflammatory markers, play a vital role in risk stratification, diagnosis, monitoring, and prognosis in COVID-19 patients. These biomarkers provide valuable insights into cardiac injury, myocardial stress, inflammation, and the prediction of adverse cardiovascular outcomes. This review aims to provide better understanding of how Cardiac biomarkers correlate to clinical manifestation of COVID-19.
Methods:
We retrieved studies from PubMed, Medline, and Google Scholars that included results on cardiac biomarkers in COVID-19. Total of 14 studies were reviewed.
Results:
8 studies showed evidence of poor progression of the disease when there is increased troponin. 6 studies out of the 14 mentioned in this review showed positive correlation between mortality and elevation in cardiac biomarkers. This shows the significance of cardiac biomarkers in predicting the mortality in patients with COVID-19.
Conclusion:
It was shown that elevated cardiac biomarkers were associated significantly to poor outcome of covid-19 infection. The outcomes that were linked to increased cardiac biomarkers included increased length of hospitalization, need of life sustaining treatment, myocarditis, invasive and non-invasive respiratory support, and even death were linked to elevated cardiac biomarkers levels.
More Related Videos
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...