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Updated: May 13, 2026

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications
Published on: September 29, 2016
Digital Light Processing of Thermoresponsive Hydrogels from Polyproline-Based Star Polypeptides
Robert D Murphy1, Muireann Cosgrave1, Nicola Judge1
1Department of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.
Abstract:
The first report of star poly(L-proline) crosslinkers is disclosed for digital light processing 3D printing of thermoresponsive hydrogels. Through chain end functionalization of star poly(L-proline)s with methacryloyl groups, access to high-resolution defined 3D hydrogel structures via digital light processing is achieved through photoinitiated free radical polymerization. Changing the poly(L-proline) molecular weight has a direct influence on both thermoresponsiveness and printability, while shape-morphing behavior can be induced thermally.
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