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Updated: Jun 13, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Function of NLRP3 inflammasome activation in multiple myeloma

Xiaorong Zhu1, Jie Yu2, Mingqiang Hua3

  • 1Department of Hematology, Baotou Central Hospital, Baotou, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|September 13, 2024
PubMed
Summary

Activation of the NLRP3 inflammasome in multiple myeloma cells promotes drug resistance. This pathway inhibits myeloma cell apoptosis induced by common treatments like dexamethasone and bortezomib.

Keywords:
NLRP3 inflammasomechemotherapeutic drugsmultiple myelomathe drug resistance

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