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Updated: Jun 13, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

[Post-stroke cognitive impairment in young patients].

L A Shchepankevich^1,2, K V Rerikh^1,2, I A Gribacheva¹

¹Novosibirsk State Medical University, Novosibirsk, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova

|September 13, 2024

Summary

Cortexin treatment improved cognitive function and quality of life in young ischemic stroke patients. Cognitive and quality of life scores significantly improved after Cortexin therapy, showing sustained benefits.

Keywords:

Cortexin cognitive deficits of the young neurotrophins poststroke cognitive impairment rehabilitation

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Last Updated: Jun 13, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients

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Published on: March 11, 2021

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Published on: December 29, 2023

Area of Science:

Neurology
Neuroscience
Pharmacology

Background:

Ischemic stroke significantly impacts cognitive function and quality of life in young adults.
Cognitive deficits are common sequelae following ischemic stroke, affecting daily living.
Effective therapeutic interventions for post-stroke cognitive impairment are crucial.

Purpose of the Study:

To evaluate the efficacy and safety of Cortexin treatment in young patients (18-45 years) recovering from ischemic stroke.
To assess the impact of Cortexin on cognitive functions, including attention, memory, and executive functions.
To determine the effect of Cortexin on the quality of life in post-stroke patients.

Main Methods:

An open prospective observational study involving 30 young ischemic stroke patients.
Neuropsychological assessment using the Montreal Cognitive Assessment (MoCA) test.
Quality of life evaluation using the Short Form-36 (SF-36) questionnaire before and after Cortexin treatment.

Main Results:

Significant improvements in MoCA scores were observed by the end of the second Cortexin treatment course (28.4±1.3 points).
Cognitive improvements included enhanced attention, short-term memory, and executive functions, with sustained benefits.
Quality of life scores (SF-36) showed significant improvement from the fourth visit onwards, indicating a positive impact on daily life.

Conclusions:

Cortexin therapy is effective in improving cognitive deficits in young individuals during the post-stroke period.
Cortexin treatment demonstrated a positive and sustained effect on the quality of life for young stroke survivors.
Cortexin was found to be safe and well-tolerated in this patient population.