The Effects of Fisetin on Reducing Biological Aging: A Pilot Study

Fisetin, a natural flavonoid compound, is a senolytic agent that has shown promise in extending the lifespan of aging mice. Our goal was to determine whether Fisetin can reduce human biological aging, as verified by the TruAge test. This would be the first study in healthy human adults over the age of 50 years old to determine if Fisetin can reduce their biological age. Fisetin 500 mg daily was administered for one week per month for six months. The results showed that four out of ten healthy adults experienced a reduction in biological aging, five out of ten saw an increase, and one out of ten had no change. No adverse effects were noted among the ten subjects. Telomere lengths did not statistically change with the use of Fisetin. Because five of ten had an increase in biological age, taking Fisetin as an anti- aging agent is not recommended until more extensive studies are done.