Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
Factors Affecting Illness01:18

Factors Affecting Illness

5.4K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.4K
Skin Cancer01:30

Skin Cancer

5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

24
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
24
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

21
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical utility of coronary CT angiography to guide PCI: a survey among P4 investigators.

The international journal of cardiovascular imaging·2025
Same author

Validation of contemporary methods to assess vessel specific myocardial mass.

Cardiovascular revascularization medicine : including molecular interventions·2025
Same author

Impact of Bifurcation Lesions on Outcomes After FFR-Guided PCI or CABG.

Circulation. Cardiovascular interventions·2024
Same author

Gender-Based Specificities of Fractional Flow Reserve Measurement.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2024
Same author

Impact of Robotic Percutaneous Coronary Intervention (R-PCI) With and Without CCTA-Guidance on Clinical Outcomes and Hospital Economics: A Single Center Registry.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2024
Same author

Sex Differences in Patients Undergoing FFR-Guided PCI or CABG in the FAME 3 Trial.

JACC. Cardiovascular interventions·2024
Same journal

Seeing the Unseen: Deep Learning and the Pre-Therapy Cardiac Phenotype in Cardiotoxicity.

JACC. Cardiovascular imaging·2026
Same journal

Measure Simply, Stratify Better: Suspected Myocarditis-The Clinical Case for Atrial LAS in Routine CMR.

JACC. Cardiovascular imaging·2026
Same journal

Expert Human Readers vs ECG Criteria for Detecting Left Ventricular Hypertrophy: A CMR-Based Comparison.

JACC. Cardiovascular imaging·2026
Same journal

Secondary Tricuspid Regurgitation in Pulmonary Hypertension: Marker, Mediator, and Potential Target?

JACC. Cardiovascular imaging·2026
Same journal

Integrated Coronary CT Angiography Assessment of Plaque Vulnerability and Clinical Outcomes: The Morphology-Inflammation-Burden (MIB) Score.

JACC. Cardiovascular imaging·2026
Same journal

Coronary CT Angiography: New Insights in Search of Vulnerable Plaques and Patients.

JACC. Cardiovascular imaging·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.4K

Predictors for Vulnerable Plaque in Functionally Significant Lesions.

Seokhun Yang1, Doyeon Hwang1, Koshiro Sakai2

  • 1Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul National University of College of Medicine, Seoul, South Korea.

JACC. Cardiovascular Imaging
|September 13, 2024
PubMed
Summary
This summary is machine-generated.

Vulnerable plaque in functionally significant coronary lesions can be predicted using pullback pressure gradient (PPG) and fractional flow reserve (FFR) measurements. This combination accurately identifies high-risk plaques without needing further anatomical or plaque imaging.

Keywords:
fractional flow reservemyocardial ischemiaplaque rupturepullback pressure gradientsthin-cap fibroatheroma

More Related Videos

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.8K
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

2.0K

Related Experiment Videos

Last Updated: May 1, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.4K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.8K
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

2.0K

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Medical imaging

Background:

  • Vulnerable plaque is crucial in predicting cardiovascular events.
  • Identifying vulnerable plaque in functionally significant lesions is clinically important.

Purpose of the Study:

  • To identify predictors of vulnerable plaque in functionally significant coronary lesions.
  • To assess the role of pullback pressure gradient (PPG) and fractional flow reserve (FFR) in predicting vulnerable plaque.

Main Methods:

  • A prospective, multicenter study involving 95 patients with FFR ≤0.80.
  • Coronary computed tomographic angiography and optical coherence tomography were used for plaque analysis.
  • PPG and FFR data were analyzed alongside clinical and angiographic findings.

Main Results:

  • Vulnerable plaque was present in 55.8% of lesions.
  • Both PPG and FFR were significant predictors of vulnerable plaque (P < 0.05).
  • Combined PPG >0.65 and FFR ≤0.70 showed the highest prevalence of vulnerable plaque (88.2%).

Conclusions:

  • PPG combined with FFR can predict vulnerable plaque in low-FFR lesions.
  • No additional anatomical or plaque characteristics are needed for prediction.
  • This approach aids in identifying high-risk coronary lesions.