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TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell
Grégoire Gessain1,2, Ahmed-Amine Anzali1, Marvin Lerousseau3,4,5
1INSERM U1015, Gustave Roussy Cancer Campus, Bâtiment de Médecine Moléculaire, Villejuif, France.
Cancer Discovery
|September 13, 2024
Abstract
Significance:
Novel individual biomarkers are needed to guide therapeutic decisions for patients with head and neck cancer. We report for the first time, granulomas of TREM2-expressing multinucleated giant macrophages in keratin-rich tumor niches, as a biomarker of favorable prognosis and developed a deep-learning model to automate its quantification on routinely stained pathological slides.
