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Microenvironmental host-microbe interactions in chronic inflammatory skin diseases.

Lene Bay1, Gregor Borut Jemec2,3, Hans Christian Ring2

  • 1Bacterial Infection Biology, Department of Immunology and Microbiology, Costerton Biofilm Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|September 13, 2024
PubMed
Summary

Microbial dysbiosis plays a role in chronic inflammatory skin diseases. Local microenvironment factors significantly influence skin microbiota composition and function in these conditions.

Keywords:
Skin microenvironmenthost‐microbe interactionsinflammatory skin diesases

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Area of Science:

  • Dermatology
  • Microbiology
  • Immunology

Background:

  • Microbial dysbiosis is increasingly recognized in chronic inflammatory skin diseases.
  • The skin's local microenvironment is crucial for shaping the skin microbiota.
  • Factors like nutrients, pH, and antimicrobial peptides influence microbial composition.

Purpose of the Study:

  • To review the pathogenic crosstalk between the host and microbiota in chronic inflammatory skin diseases.
  • To explore the influence of the skin's physical, chemical, and biological microenvironments on dysbiosis.

Main Methods:

  • Literature review of microbiome studies in inflammatory skin diseases.
  • Analysis of the interplay between host immunity and microbial changes.
  • Examination of environmental factors affecting skin microbiota.

Main Results:

  • Skin dysbiosis is linked to pathogenesis in diseases like atopic dermatitis and hidradenitis suppurativa.
  • Aberrant host immune responses correlate with significant skin dysbiosis.
  • Local microenvironmental factors directly impact skin microbiota alterations.

Conclusions:

  • The local microenvironment is a key determinant of skin dysbiosis in inflammatory skin diseases.
  • Understanding host-microbiota interactions within the microenvironment is essential for therapeutic strategies.
  • Further research is needed to elucidate the precise mechanisms of this crosstalk.