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Vitamin C and suicidal ideation: A cross-sectional and Mendelian randomization study
Jiabei Wu1, Jinglian Li1, Rui Yan1
1Nursing College of Shanxi Medical University, Taiyuan, China.
Journal of Affective Disorders
|September 13, 2024
Summary
Higher vitamin C intake shows a negative association with suicidal ideation. However, genetic analysis does not confirm a causal link between vitamin C levels and the development of suicidal thoughts.
Area of Science:
- Nutritional Psychiatry
- Epidemiology
- Genetic Epidemiology
Background:
- Low antioxidant vitamin levels are linked to suicide attempts.
- The specific relationship between vitamin C and suicidal ideation requires further investigation.
Purpose of the Study:
- To investigate the effect of vitamin C on suicidal ideation.
- To explore the causal relationship using Mendelian randomization (MR).
Main Methods:
- Cross-sectional analysis of 28,623 participants from the 2005-2018 National Health and Nutrition Examination Survey (NHANES).
- Suicidal ideation assessed using the Patient Health Questionnaire-9 (PHQ-9).
- Weighted multiple linear regression, smooth curve fitting, and Mendelian randomization (MR) were employed.
Main Results:
- A negative association was observed between vitamin C levels and suicidal ideation.
- Each unit increase in vitamin C was associated with a 37% reduction in suicidal ideation risk.
- Mendelian randomization analysis did not reveal a significant causal relationship.
Conclusions:
- Dietary vitamin C intake is negatively associated with suicidal ideation.
- Genetic evidence does not support a causal role for vitamin C in the development of suicidal ideation.
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