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Updated: Jun 13, 2025
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Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
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Apoptotic Vesicles: Therapeutic Mechanisms and Critical Issues
1South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Journal of Dental Research
|September 13, 2024
Summary
Apoptotic vesicles (apoVs), generated during programmed cell death, show therapeutic potential for various diseases and applications like drug delivery. This review covers their history, current research, and future challenges.
Area of Science:
- Cell Biology
- Biochemistry
- Biotechnology
Background:
- Apoptosis is a crucial process for tissue homeostasis.
- Apoptotic vesicles (apoVs) are released during apoptosis, carrying cellular components.
- ApoVs have demonstrated potential in treating inflammation, tumors, and immune disorders.
Purpose of the Study:
- To review the historical research of apoVs.
- To summarize current preclinical and clinical studies involving apoVs.
- To discuss potential challenges and future directions for apoV applications.
Main Methods:
- Literature review of historical and recent studies on apoVs.
- Analysis of preclinical and clinical trial data.
- Synthesis of information on apoV composition and function.
Main Results:
- ApoVs contain diverse biomolecules (proteins, RNAs, lipids) from parent cells.
- Therapeutic applications include inflammation, tumors, immune disorders, and tissue regeneration.
- ApoVs are being explored as drug carriers, vaccine components, and diagnostic tools.
Conclusions:
- ApoVs represent a promising therapeutic and diagnostic tool.
- Clinical trials are underway for conditions like osteoarthritis and bone regeneration.
- Further research is needed to address challenges in apoV application.
Keywords:
apoptosisapoptotic bodieschronic inflammationclinical trialextracellular vesicletherapeuticsMore Related Videos
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