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Related Experiment Videos

Auditory and vestibular function in hyperbaric oxygen.

R R Marsh, C J Lambersten, D M Schwartz

    Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
    |June 1, 1985
    PubMed
    Summary
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    High oxygen therapy has risks. This study found no hearing or balance issues in humans exposed to 100% oxygen at high pressure, suggesting these functions are not limited by oxygen toxicity.

    Area of Science:

    • Environmental Medicine
    • Hyperbaric Physiology
    • Otolaryngology

    Background:

    • High partial pressures of oxygen (hyperoxia) offer therapeutic benefits but are limited by oxygen toxicity.
    • Known risks include pulmonary damage, visual impairment, and convulsions, but organ-specific dose-effect relationships are not well-defined.
    • Auditory and vestibular functions are crucial for overall well-being and performance, particularly in demanding environments.

    Purpose of the Study:

    • To evaluate the effects of hyperoxic exposure on auditory and vestibular function in humans.
    • To determine if ototoxicity is a limiting factor for high-pressure oxygen exposure.
    • To contribute to understanding organ oxygen tolerance in humans.

    Main Methods:

    • Human subjects were exposed to 100% oxygen at 3 atmospheres absolute (ATA) for 2 to 3.5 hours.

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  • Auditory function was assessed using standard audiometric tests.
  • Vestibular function was evaluated through tests of equilibrium and balance.
  • Assessments were conducted before, during, and after hyperoxic exposure.

    • Main Results:

    • No statistically significant alterations in hearing thresholds were detected during or after hyperoxic exposure.
    • No changes in equilibrium or balance were observed in subjects exposed to 100% oxygen at 3 ATA.
    • These findings indicate that auditory and vestibular systems are tolerant to the tested hyperoxic conditions.

    Conclusions:

    • Exposure to 100% oxygen at 3 ATA for up to 3.5 hours does not adversely affect human auditory or vestibular function.
    • Otoxicity is unlikely to be a primary limiting factor for hyperoxic exposures under these specific conditions.
    • Further research can explore dose-effect relationships for other organs and functions.