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Morphologic changes in the guinea pig cochlea following cochleostomy--a preliminary scanning electron microscope
Summary
Surgically creating an endolymphatic-perilymphatic shunt (cochleosacculotomy) in normal animals caused progressive sensory cell degeneration in the cochlear duct. This study investigated the effects of labyrinthine fistulization on the inner ear.
Area of Science:
- Otolaryngology
- Neuroscience
- Histopathology
Background:
- Endolymphatic-perilymphatic shunt (cochleosacculotomy) is a proposed treatment for endolymphatic hydrops.
- The effects of labyrinthine fistulization on the inner ear require preliminary investigation.
Purpose of the Study:
- To reproduce the cochleosacculotomy procedure in normal animals.
- To assess the histopathological consequences of cochlear duct fistulization.
Main Methods:
- Cochlear duct fistulization was performed in 15 normal animals using a tungsten wire.
- The procedure involved accessing the cochlear partition via the round window.
- Scanning electron microscopy was used to examine cochlear histopathology at regular intervals.
Main Results:
- Discrete, permanent fistulization of the cochlear duct led to progressive sensory cell degeneration.
- Histopathological changes were observed in the organ of Corti region.
Conclusions:
- Cochleosacculotomy in normal guinea pigs results in sensory cell degeneration.
- Findings contrast with reported human experiences, warranting further investigation.