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Updated: May 5, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
Targeted Prostate Biopsy: How, When, and Why? A Systematic Review.
Giacomo Rebez1, Maria Barbiero2, Franco Alchiede Simonato3
1Urology Unit, Dipartimento Chirurgico Area Isontina, Azienda Sanitaria Universitaria Giuliano Isontina, 34170 Gorizia, Italy.
Multiparametric MRI-guided targeted prostate biopsies improve the detection of significant prostate cancer. This advanced technique enhances diagnostic accuracy, reduces unnecessary procedures, and improves patient outcomes by precisely targeting suspicious areas.
Area of Science:
- Urology
- Oncology
- Radiology
Background:
- Prostate cancer is a leading cancer diagnosis in men.
- Accurate diagnosis is crucial for effective prostate cancer treatment.
- Multiparametric magnetic resonance imaging (mpMRI) offers advanced visualization of the prostate.
Purpose of the Study:
- To review technological advancements in targeted prostate biopsies using mpMRI.
- To evaluate optimal application conditions and benefits of mpMRI-guided biopsies.
- To compare mpMRI-guided targeted biopsies with traditional methods.
Main Methods:
- Systematic literature review of studies from January 2015 to December 2024.
- Searched PubMed, Scopus, and Web of Science databases.
- Compared transrectal ultrasound-guided systematic biopsies with mpMRI-guided targeted biopsies (fusion and cognitive).
Main Results:
- mpMRI-guided targeted biopsies significantly increase the detection of clinically significant prostate cancer.
- These methods reduce the diagnosis of insignificant cancers and the need for repeat biopsies.
- Diagnostic accuracy and patient outcomes are maintained or improved.
Conclusions:
- mpMRI-guided targeted biopsies are superior for detecting significant prostate cancer.
- This approach minimizes overdiagnosis and overtreatment risks.
- Integrating mpMRI into prostate biopsy protocols enhances diagnostic precision and patient quality of life.
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