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The Interplay between Structural Inequality, Allostatic Load, Inflammation, and Cancer in Black Americans: A
Ashanda R Esdaille1,2, Nelson Kevin Kuete1, Vivian Ifunanya Anyaeche1
1Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Cancers
|September 14, 2024
Summary
Racial healthcare disparities negatively impact Black Americans
Area of Science:
- Public Health
- Health Disparities
- Socioeconomic Factors
Background:
- Racial healthcare disparities are well-documented, linked to adverse social determinants of health.
- Residential location significantly influences individual health outcomes.
- Socioeconomically disadvantaged areas present obstacles to healthy lifestyles for Black Americans.
Purpose of the Study:
- To review associations between healthcare disparities, chronic stress, allostatic load, inflammation, and cancer in Black Americans.
- To discuss potential mechanisms and solutions for these disparities.
Main Methods:
- Narrative review of existing literature.
- Analysis of associations between social determinants, stress, allostatic load, inflammation, and cancer risk.
Main Results:
- Adverse living conditions, environmental factors, and systemic biases contribute to allostatic load in Black Americans.
- Decreased physical activity and limited access to healthy food exacerbate oxidative stress and inflammation.
- These factors are fundamental drivers of cardiovascular disease and cancer.
Conclusions:
- Healthcare disparities, chronic stress, and environmental factors create a pathway to increased cancer risk in Black Americans.
- Further research is crucial to address cancer disparities effectively.
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