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Roles of M1 Macrophages and Their Extracellular Vesicles in Cancer Therapy

Wenli Zhou1, Fengtang Yang1, Xiuzhen Zhang1

  • 1School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, China.

Cells
|September 14, 2024
PubMed

Insights

M1 macrophage-derived extracellular vesicles (M1-EVs) show promise in cancer therapy by delivering microRNAs and drugs. Reprogramming M2 macrophages to M1 may also enhance cancer treatment strategies.

Area of Science:

  • Immunology
  • Cancer Biology
  • Nanomedicine

Background:

  • Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment, exhibiting functional heterogeneity.
  • TAMs exist as M1 and M2 subpopulations with opposing roles in immune response and tissue repair.
  • Extracellular vesicles (EVs) mediate intercellular communication, carrying molecular cargo like microRNAs from parent cells to target cells.

Purpose of the Study:

  • To review the therapeutic potential of M1 macrophage-derived EVs (M1-EVs) in cancer treatment.
  • To explore the impact of M1-EVs on tumors via microRNA transfer.
  • To discuss M1-EVs as drug delivery vehicles and the strategy of reprogramming M2 macrophages to M1.

Main Methods:

  • Literature review on M1-EVs and their role in cancer.
  • Analysis of microRNA transfer mechanisms by M1-EVs.
  • Exploration of M2 to M1 macrophage reprogramming strategies.

Main Results:

  • M1-EVs can transfer microRNAs to tumor cells, influencing their behavior.
  • M1-EVs demonstrate potential as carriers for targeted drug delivery in cancer therapy.
  • Reprogramming M2 macrophages into M1 macrophages presents a viable therapeutic avenue.

Conclusions:

  • M1-EVs are significant in cancer therapy through microRNA delivery and drug loading.
  • Reprogramming M2 macrophages to M1 offers a promising strategy for cancer treatment.
Keywords:
M1 macrophageM2 macrophagecancerexosomeextracellular vesicles

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