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In Vitro Modulation of Human Foam Cell Formation and Adhesion Molecules Expression by Ginger Extracts Points to
Alessandro Scalia1, Maxime Coquay1,2, Nadège Kindt1,3
1Department of Cardiology, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000 Mons, Belgium.
Insights
Ginger extracts show potential in preventing cardiovascular disease (CVD) by inhibiting LDL oxidation and foam cell formation. Further research will identify active compounds and mechanisms for novel CVD prevention strategies.
Area of Science:
- Cardiovascular Science
- Nutraceuticals
- Biochemistry
Background:
- Cardiovascular disease (CVD) deaths are rising globally, necessitating effective prevention strategies.
- Atherosclerosis, a primary CVD precursor, involves LDL oxidation, inflammation, and foam cell formation in the endothelium.
- Ginger possesses known antioxidative and anti-inflammatory properties.
Purpose of the Study:
- To investigate the potential of ginger extracts in preventing cardiovascular disease initiation.
- To evaluate the effects of ginger on LDL oxidation and foam cell formation.
- To identify active ginger fractions with antioxidative properties relevant to atherosclerosis.
Main Methods:
- Analysis of ginger extract fractions for antioxidative effects.
- Assessment of ginger's impact on LDL oxidation and foam cell formation.
- Exploration of microfluidic models for studying ginger's effects on monocyte recruitment.
Main Results:
- Specific ginger fractions (D and E) demonstrated significant antioxidative effects.
- Ginger extracts showed promise in inhibiting LDL oxidation and reducing foam cell formation.
- Further investigation is required to pinpoint active compounds and their mechanisms.
Conclusions:
- Ginger extracts represent a potential novel therapeutic approach for cardiovascular disease prevention.
- Active compounds within ginger fractions D and E warrant further identification and mechanistic study.
- Microfluidic models may provide valuable insights into ginger's role in atherogenesis.
Abstract:
Recent findings from the World Heart Federation (WHF) reported a significant increase in cardiovascular disease (CVD)-related deaths, highlighting the urgent need for effective prevention strategies. Atherosclerosis, a key precursor to CVD, involves the accumulation of low-density lipoprotein (LDL) and its oxidation within the endothelium, leading to inflammation and foam cell formation. Ginger extracts, known for their antioxidative and anti-inflammatory properties, show promise in preventing CVD initiation by inhibiting LDL oxidation and reducing foam cell formation. Our results revealed that the active fractions in ginger extracts had antioxidative effects, particularly fractions D and E. Further research is needed to identify the active compounds in these fractions and understand their mechanisms of action. In this context, microfluidic models could offer insights into the effects of ginger on monocyte recruitment in a more physiologically relevant context. Overall, ginger extracts represent a potential novel treatment for preventing CVD initiation, but additional studies are necessary to identify the active molecules in these fractions.
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