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Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases
Haoyuan Deng1, Ding Ding2, Yu Ma3
1Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China.
Nicotinamide mononucleotide (NMN) shows promise in protecting against cardiovascular diseases by boosting NAD+ levels. Clinical studies suggest NMN supplementation is safe and may offer cardiovascular benefits.
Area of Science:
- Biochemistry
- Cardiovascular Biology
- Nutraceutical Science
Background:
- Nicotinamide adenine dinucleotide (NAD+) is vital for cellular processes like energy metabolism and DNA repair.
- Altered NAD+ levels are linked to cardiovascular dysfunction and diseases.
- Nicotinamide mononucleotide (NMN) is a NAD+ precursor with demonstrated benefits in preclinical cardiovascular studies.
Purpose of the Study:
- To review the impact of NMN on cardiovascular diseases.
- To explore NMN's role as a nutraceutical and potential therapeutic agent for cardiovascular protection.
- To highlight the link between NMN supplementation and cardiovascular health.
Main Methods:
- Systematic review of in vivo and in vitro studies.
- Analysis of clinical trial data on NMN efficacy and safety.
- Literature search focusing on NMN's mechanism in NAD+ biosynthesis and cardiovascular effects.
Main Results:
- NMN alleviates cardiovascular conditions like heart failure, atherosclerosis, and ischemia/reperfusion injury.
- NMN's pharmacological effects are primarily mediated through NAD+ biosynthesis.
- Clinical studies indicate NMN supplementation is safe and potentially beneficial for cardiovascular protection.
Conclusions:
- NMN demonstrates significant potential in preventing and treating cardiovascular diseases.
- NMN supplementation may serve as a valuable strategy for cardiovascular health maintenance.
- Further research supports NMN's therapeutic role in managing cardiovascular dysfunction.
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