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Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action

Wamidh H Talib1,2, Media Mohammad Baban3, Mais Fuad Bulbul3

  • 1Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan.

International Journal of Molecular Sciences
|September 14, 2024
PubMed

Insights

Natural products show promise in targeting cancer

Area of Science:

  • Oncology
  • Metabolic Research
  • Natural Products Chemistry

Background:

  • Cancer involves uncontrolled cell growth and metabolic dysregulation.
  • Metabolic alterations like the Warburg effect are key research areas.
  • Targeted metabolic therapies offer potential for cancer treatment.

Purpose of the Study:

  • To review recent research on natural products' effects on cancer metabolism.
  • To identify natural products targeting cancer's altered metabolic pathways.
  • To explore their mechanisms of action on cellular energetics.

Main Methods:

  • Literature review of studies on natural products and cancer metabolism.
  • Selection of natural products based on their metabolic targeting capabilities.
  • Analysis of identified targets and mechanisms of action.

Main Results:

  • Natural products can influence key metabolic pathways in cancer cells.
  • Specific natural products demonstrate efficacy in targeting cancer metabolism.
  • Mechanisms involve modulation of cellular energetics and metabolic processes.

Conclusions:

  • Natural products represent a viable strategy for targeting cancer metabolism.
  • They can be used as standalone or complementary therapies.
  • Further research supports their integration into cancer treatment regimens.
Keywords:
Warburg effectangiogenesisanticancerhuman healthmetastasisnatural products

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