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A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications
Giovanna Aquino1, Gianluca Viscusi2, Massimo Christian D'Alterio3
1Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.
International Journal of Molecular Sciences
|September 14, 2024
Summary
This study developed biodegradable electrospun membranes using Poly(L-lactic acid) (PLLA) loaded with spironolactone to mimic medicinal mushroom compounds for wound healing applications.
Area of Science:
- Biomaterials Science
- Polymer Science
- Drug Delivery Systems
Background:
- Electrospinning creates micro/nanofibers for biomedical uses, offering high drug loading and tunable release.
- Poly(L-lactic acid) (PLLA) is a biodegradable and bioabsorbable polymer with excellent properties, suitable for various medical applications.
- Electrospun PLLA scaffolds are explored for wound dressings, sutures, drug delivery, and tissue engineering.
Purpose of the Study:
- To create and characterize electrospun PLLA membranes loaded with spironolactone (SP).
- To mimic the active compounds of Ganoderma lucidum (GL) for topical wound healing.
- To develop a biodegradable patch for enhanced wound healing applications.
Main Methods:
- Fabrication of electrospun PLLA membranes loaded with spironolactone.
- Characterization of membrane properties including wetting, moisture, and material resilience.
- Development of a prototype using a pure substance to represent complex GL extracts.
Main Results:
- Successful fabrication of electrospun PLLA membranes with spironolactone.
- Comprehensive characterization of the physical and material properties of the developed membranes.
- Demonstration of a viable approach for incorporating bioactive compounds into nanofibrous structures.
Conclusions:
- Electrospun PLLA membranes loaded with spironolactone show potential for wound healing applications.
- The study provides a foundation for creating biodegradable patches with complex bioactive extracts.
- This research supports the development of innovative drug delivery systems for topical treatments.
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