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Hydroxychloroquine as an Adjunct Therapy for Diabetes in Pregnancy
Nurul Iftida Basri1,2, Padma Murthi3, Rahana Abd Rahman1
1Department of Obstetrics and Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur 56000, Malaysia.
International Journal of Molecular Sciences
|September 14, 2024
Summary
This review explores hydroxychloroquine for improving pregnancy outcomes in women with diabetes. It examines hydroxychloroquine
Area of Science:
- Reproductive medicine
- Endocrinology
- Pharmacology
Background:
- Diabetes in pregnancy poses risks to both mother and fetus.
- Placental dysfunction is a key factor in adverse pregnancy outcomes associated with diabetes.
- Current treatments for diabetes in pregnancy have limitations.
Purpose of the Study:
- To review the pathophysiology of diabetes in pregnancy.
- To explore the potential of hydroxychloroquine in improving pregnancy outcomes.
- To elucidate the mechanisms of action of hydroxychloroquine in this context.
Main Methods:
- Literature review of studies on diabetes in pregnancy, placental function, and hydroxychloroquine.
- Analysis of proposed mechanisms of hydroxychloroquine's action.
- Evaluation of safety data for hydroxychloroquine use during pregnancy.
Main Results:
- Hydroxychloroquine may improve pregnancy outcomes by targeting pathways including the inflammasome complex, inflammatory cytokines, and oxidative stress.
- The drug exhibits potential antihyperglycemic effects.
- Hydroxychloroquine has a favorable safety profile for use in pregnancy.
Conclusions:
- Hydroxychloroquine presents a potential adjunct therapy for managing diabetes in pregnancy.
- Further research is warranted to confirm its efficacy and optimal use.
- Exploring hydroxychloroquine could lead to improved management strategies for diabetic pregnancies.
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