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A Transcriptomic Analysis of Laryngeal Dysplasia.
Fausto Maffini1, Daniela Lepanto1, Francesco Chu2
1Department of Surgical Pathology, European Institute of Oncology IRCCS, 20141 Milan, Italy.
International Journal of Molecular Sciences
|September 14, 2024
Summary
Transcriptional alterations in the innate immune system can classify dysplasias as aggressive or slow-progressing. This immune system insight aids in predicting disease progression and personalizing cancer treatments.
Area of Science:
- Immunology
- Oncology
- Genomics
Background:
- The innate immune system plays a role in disease progression, influencing extracellular matrix changes and amplifying inflammation.
- Infections can exacerbate disease by increasing epithelial damage and altering immune responses.
Purpose of the Study:
- To investigate the link between dysregulated immune genes and disease progression, delay, or recovery in dysplasias.
- To identify transcriptional alterations that differentiate between progressive and non-progressive dysplasias.
Main Methods:
- Utilized the Oncomine Immune Response Research Assay (OIRRA), an RNA-based next-generation sequencing (NGS) panel.
- Measured gene expression related to lymphocyte regulation, cytokine signaling, lymphocyte markers, and checkpoint pathways.
Main Results:
- Identified specific transcriptional alterations that categorize dysplasias into progressive and non-progressive types.
- Observed that immune system dysregulation influences disease behavior, including relapse rates.
Conclusions:
- Transcriptional profiling of the immune system can predict dysplasia progression and relapse.
- These findings pave the way for personalized treatment strategies, including chemotherapy, checkpoint inhibitors, and cell therapies.
