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Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells

Florin Iordache1,2, Adriana Cornelia Ionescu Petcu1, Diana Mihaela Alexandru3

  • 1Biochemistry Disciplines, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 050097 Bucharest, Romania.

International Journal of Molecular Sciences
|September 14, 2024
PubMed

Insights

Cellular senescence, a key aging process, involves epigenetic changes in stem cells. This review highlights new epigenetic targets for treating age-related diseases.

Area of Science:

  • Gerontology and Epigenetics
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Cellular senescence is a permanent cell cycle arrest, with replicative senescence linked to telomere shortening and premature senescence to stress.
  • Current treatments for senescence target epigenetic changes, including drugs, senolytics, and somatic cell reprogramming.
  • The complex interplay between genetic profiles, epigenetic modifications, and external factors like microbiota and diet in senescence remains unclear.

Purpose of the Study:

  • To review recent epigenetic modifications involved in stem cell senescence.
  • To identify novel therapeutic targets for aging-related diseases based on senescence-associated epigenetic alterations.

Main Methods:

  • Literature review of recent studies on cellular senescence and epigenetics.
  • Focus on DNA methylation, chromatin remodeling, histone modification, RNA modification, and non-coding RNA regulation.
  • Brief overview of animal models used in senescence research.

Main Results:

  • Detailed examination of various epigenetic alterations in stem cell senescence.
  • Identification of specific epigenetic mechanisms influencing senescence pathways.
  • Discussion of potential therapeutic strategies targeting these epigenetic modifications.

Conclusions:

  • Epigenetic modifications play a crucial role in stem cell senescence.
  • Understanding these epigenetic changes offers new avenues for therapeutic interventions in aging.
  • Further research is needed to elucidate the intricate interactions influencing senescence.
Keywords:
acetylationcellular senescenceepigeneticshistonemethylationstem cells

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