Association Analysis between Cognitive Function Score and Inner Macular Thickness/Visual Field Sensitivity in...

Area of Science:

• Ophthalmology
• Neurology
• Gerontology

Background:

• Previous studies explored cognitive impairment, OCT, VF, and reliability in smaller samples.
• This study specifically examined Mini-Cog scores against inner macular thickness (IMT) and VF sensitivity in glaucoma.

Purpose of the Study:

• To analyze the association between cognitive function (Mini-Cog) and ocular parameters in glaucoma patients.
• To investigate if impaired cognition correlates with glaucoma severity markers.

Main Methods:

• Retrospective analysis of 984 glaucoma patients (1897 eyes).
• Collected data on age, sex, IOP, and Mini-Cog scores; 9% had abnormal scores.
• Used mixed-effects models to assess Mini-Cog scores against IMT, PF-IMT, MD, PSD, FL, FN, and FP.

Main Results:

• Abnormal Mini-Cog scores correlated with thinner IMT and PF-IMT.
• Lower cognitive function was linked to worse mean deviation (MD) and higher false negative (FN) and false positive (FP) rates.
• No significant association was found with pattern standard deviation (PSD) or fixation losses (FL).

Conclusions:

• Glaucoma patients with poorer cognitive function exhibit more severe glaucoma-related changes.
• Findings suggest a correlation between cognitive decline and advanced glaucoma.
• Further longitudinal research is recommended to elucidate the glaucoma-cognitive impairment relationship.