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Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Extracorporeal Shock Wave Therapy (eSWT) in Spinal Cord Injury-A Narrative Review.

Józef Opara1, Robert Dymarek2, Mirosław Sopel3

  • 1Department of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland.

Journal of Clinical Medicine
|September 14, 2024
PubMed
Summary

Extracorporeal shock wave therapy (eSWT) shows promise for spinal cord injury (SCI) recovery. Clinical trials suggest eSWT may aid spinal regeneration and improve spasticity, function, and quality of life in SCI patients.

Keywords:
extracorporeal shock wave therapynarrative reviewneuromodulationneuroregenerationrecoveryspasticityspinal cord injury

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Traumatic spinal cord injury (SCI) results in irreversible motor and sensory dysfunction.
  • Current treatments for SCI lack efficacy in promoting neuronal regeneration and functional recovery.
  • Despite extensive research, experimental successes in animal models have not translated to human therapies.

Purpose of the Study:

  • To review the application of extracorporeal shock wave therapy (eSWT) in patients with spinal cord injury.
  • To explore the potential of eSWT for spinal cord regeneration and management of spasticity post-SCI.
  • To describe the hypothesized mechanisms of action for eSWT in SCI treatment.

Main Methods:

  • This is a narrative review article.
  • The review focuses on the application of extracorporeal shock wave therapy (eSWT) in SCI patients.
  • The content is organized into sections covering eSWT for spinal regeneration and eSWT for spasticity.

Main Results:

  • Limited clinical trials indicate eSWT's potential in influencing spinal regeneration.
  • eSWT is presented as an innovative, safe, and cost-effective treatment for SCI.
  • Some studies report improvements in spasticity, walking, urological function, and quality of life.

Conclusions:

  • eSWT demonstrates potential as a novel therapeutic approach for spinal cord injury.
  • The therapy may offer benefits in functional recovery and improving the quality of life for SCI patients.
  • Further clinical investigation is warranted to fully establish the efficacy and mechanisms of eSWT in SCI.