Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Trait and State Self-Esteem02:08

Trait and State Self-Esteem

The term self-esteem is often used generically, to refer to how people feel about themselves. However, according to research, there are three distinct constructs that should not be used interchangeably (Brown & Marshall, 2006).
Self-Discrepancy Theory02:45

Self-Discrepancy Theory

One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.
Actin Treadmilling01:18

Actin Treadmilling

Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anticoagulation, recurrent thrombosis, and major bleeding in antiphospholipid syndrome: UK multicenter observational study.

Blood advances·2026
Same author

Practical Considerations for the Use of the Rapid AcuStar<sup>®</sup> ADAMTS13 Activity Assay in the Diagnosis of Acute Thrombotic Thrombocytopenic Purpura (TTP).

Journal of clinical medicine·2024
Same author

Revisiting the full blood count: Circulating blood cells and their role in coagulation.

British journal of haematology·2024
Same author

Restoring discarded porcine lungs by ex vivo removal of neutrophil extracellular traps.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2024
Same author

Fibrinogen binding to histones in circulation protects against adverse cellular and clinical outcomes.

Journal of thrombosis and haemostasis : JTH·2024
Same author

Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality.

Blood advances·2024

Related Experiment Video

Updated: Jun 21, 2026

Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila
18:08

Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila

Published on: September 28, 2010

46.7K

The Highs and Lows of ADAMTS13 Activity.

Rebecca J Shaw1,2, Simon T Abrams2, Samuel Badu1

  • 1Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, UK.

Journal of Clinical Medicine
|September 14, 2024
PubMed
Summary

Severe ADAMTS13 deficiency (<10 iu/dL) diagnoses thrombotic thrombocytopenic purpura (TTP), causing microthrombi. Low ADAMTS13 activity also impacts patients in remission and may affect other thrombotic diseases.

Keywords:
ADAMTS13TTPrecombinantvWF

More Related Videos

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

8.2K
Physical Activity Measurement in Children Accepting Table Tennis Training
06:51

Physical Activity Measurement in Children Accepting Table Tennis Training

Published on: July 27, 2022

1.9K

Related Experiment Videos

Last Updated: Jun 21, 2026

Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila
18:08

Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila

Published on: September 28, 2010

46.7K
Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

8.2K
Physical Activity Measurement in Children Accepting Table Tennis Training
06:51

Physical Activity Measurement in Children Accepting Table Tennis Training

Published on: July 27, 2022

1.9K

Area of Science:

  • Hematology
  • Vascular Biology
  • Thrombosis Research

Background:

  • Severe ADAMTS13 deficiency (<10 iu/dL) is diagnostic of thrombotic thrombocytopenic purpura (TTP).
  • This deficiency leads to ultra-large von Willebrand factor (vWF) multimers, platelet aggregation, and life-threatening microthrombi.
  • The clinical significance extends beyond acute TTP episodes, affecting patients in remission.

Purpose of the Study:

  • To discuss the effects of low ADAMTS13 activity in congenital and immune-mediated TTP patients.
  • To explore the impact of low ADAMTS13 activity in patients during clinical remission.
  • To investigate the broader clinical effects of low ADAMTS13 activity on the vascular endothelium and its potential in other thrombotic diseases.

Main Methods:

  • Review of clinical data and emerging evidence on ADAMTS13 activity.
  • Analysis of the impact of low ADAMTS13 levels in TTP patients at presentation and remission.
  • Exploration of ADAMTS13's role in non-TTP thrombotic conditions.

Main Results:

  • Low ADAMTS13 activity has implications beyond acute TTP, affecting patients in remission.
  • Emerging evidence suggests clinical effects of low ADAMTS13 activity in diseases outside of TTP.
  • Low ADAMTS13 activity impacts the vascular endothelium.

Conclusions:

  • Low ADAMTS13 activity is a critical factor in TTP, with ongoing implications for patients.
  • The scope of low ADAMTS13 activity's impact may extend to other thrombotic conditions.
  • Recombinant ADAMTS13 therapy holds potential for treating various thrombotic disease states.