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Stage-Specific Plasma Metabolomic Profiles in Colorectal Cancer.

Tetsuo Ishizaki1, Masahiro Sugimoto2,3, Yu Kuboyama1

  • 1Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku 160-0023, Tokyo, Japan.

Journal of Clinical Medicine
|September 14, 2024
PubMed
Summary

Colorectal cancer (CRC) patients show distinct metabolic profiles. Acetylated polyamines are elevated in stage IV CRC, suggesting potential for distinguishing advanced disease stages.

Keywords:
capillary electrophoresis–mass spectrometrycolorectal cancerliquid chromatography–mass spectrometrymass spectrometrymetabolomicsmetastasis

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Area of Science:

  • Metabolomics
  • Oncology
  • Biochemistry

Background:

  • Colorectal cancer (CRC) is a significant global health concern.
  • Understanding metabolic alterations in CRC progression is crucial for diagnosis and treatment.
  • Current diagnostic methods for CRC require improvement, especially for early detection and staging.

Purpose of the Study:

  • To investigate the metabolomic profiles of patients with colorectal cancer (CRC) across different disease stages.
  • To identify specific metabolites that change with CRC progression.
  • To evaluate the potential of identified metabolites as diagnostic markers for CRC staging.

Main Methods:

  • Analysis of plasma samples from 255 subjects, including CRC patients (stages I-IV), polyps, and controls.
  • Utilized capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) and liquid chromatography triple quadrupole mass spectrometry (LC-MS/MS).
  • Comprehensive analysis of hydrophilic metabolites with data validation across two independent groups.

Main Results:

  • Elevated concentrations of acetylated polyamines (N1-acetylspermine, N1,N12-diacetylspermine) were observed in stage IV CRC compared to earlier stages.
  • Non-acetylated polyamines (spermine, spermidine) showed increasing trends from polyp to stage IV.
  • Decreasing trends were noted for metabolites like histidine and o-acetylcarnitine across disease stages.

Conclusions:

  • Metabolic profiles, particularly polyamine levels, exhibit stage-specific changes in colorectal cancer.
  • Acetylated polyamines demonstrate potential as diagnostic markers for distinguishing advanced (stage IV) CRC from other stages.
  • These findings contribute to understanding CRC metabolomics and may inform future diagnostic strategies.