Related Experiment Video
Updated: Jun 13, 2025
14:18
Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
Published on: October 13, 2023
1.7K
Pathogenic Immunoglobulin A-Producing Cells in Immunoglobulin A Nephropathy.
Yuko Makita1,2,3, Heather N Reich1,3
1Division of Nephrology, University Health Network, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Journal of Clinical Medicine
|September 14, 2024
Summary
Immunoglobulin A nephropathy (IgAN), a major cause of kidney failure, may stem from abnormal mucosal immune responses. This review examines how mucosal immune cells contribute to IgAN development.
Area of Science:
- Nephrology
- Immunology
- Gastroenterology
Background:
- Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease globally, frequently leading to kidney failure.
- Infections can worsen IgAN symptoms, and abnormal mucosal immune responses are increasingly implicated in its development.
- The precise triggers, sites, and mechanisms of nephritis-inducing IgA production in IgAN are not fully understood.
Purpose of the Study:
- To review recent advancements in understanding the role of the mucosal immune system in IgAN pathogenesis.
- To explore the contribution of IgA-producing cells originating from mucosal tissues to IgAN development.
Main Methods:
- Focused review of current literature on mucosal immunity and IgAN.
- Analysis of emerging data on immunopathogenesis of IgAN.
Main Results:
- Emerging data highlight the significant role of mucosal immune responses in IgAN.
- Mucosal-derived IgA-producing cells are increasingly recognized as contributors to the disease.
Conclusions:
- The mucosal immune system plays a critical role in the development of Immunoglobulin A nephropathy.
- Further research into mucosal-derived IgA is crucial for understanding and potentially treating IgAN.
Related Concept Videos
01:20Renal Corpuscle
1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
01:23Cells of the Adaptive Immune Response
971
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
971
01:36Humoral Immune Responses
72.2K
Overview
72.2K
01:40Cell-mediated Immune Responses
67.8K
Overview
67.8K
01:31Hybridoma Technology
14.1K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
14.1K
01:10Nephrons
2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K