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Updated: Jun 13, 2025

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Prospective Analysis of the Effectiveness of Targeted Botulinum Toxin Type A Injection Using an Ultrasound-Guided
Hyun-Jung Ryoo1, Ho Kwon2, Jae-Seon Choi1
1Department of Plastic and Reconstructive Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Republic of Korea.
Ultrasound-guided botulinum toxin type A (BoNT-A) injections for masseter hypertrophy are more effective than traditional methods. This technique enhances accuracy and provides superior muscle thickness reduction.
Area of Science:
- Cosmetic surgery
- Medical aesthetics
- Facial rejuvenation
Background:
- Botulinum toxin type A (BoNT-A) injections are common for masseter hypertrophy.
- Traditional injections rely on landmark-guided, blind techniques.
- Ultrasound (US)-guided injections offer real-time visualization for improved accuracy.
Purpose of the Study:
- To compare the efficacy of US-guided versus landmark-guided BoNT-A injections for masseter hypertrophy.
- To assess the impact of each injection method on masseter muscle thickness.
Main Methods:
- A trial involving 50 patients undergoing BoNT-A injections.
- One side of the face received landmark-guided injection; the other received US-guided injection.
- Muscle thickness was measured using ultrasound in upper, middle, and lower regions pre- and post-procedure.
Main Results:
- Both methods significantly reduced muscle thickness one month post-injection.
- US-guided injections showed statistically superior reduction in muscle thickness in all areas (upper, middle, lower).
- Significant differences (p < 0.0001 for upper and middle; p = 0.0004 for lower) favored US-guided technique.
Conclusions:
- Ultrasound-guided single-point injection is a more effective and accurate method for BoNT-A delivery.
- This technique offers enhanced precision compared to conventional landmark-guided injections.
- US-guidance improves outcomes in treating masseter hypertrophy.
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