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Food intolerance.

M H Lessof

    Scandinavian Journal of Gastroenterology. Supplement
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Food intolerance symptoms stem from enzyme issues, drug effects, or immune responses. Diagnosis involves food elimination and blind challenges to identify triggers and mediators.

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    Area of Science:

    • Gastroenterology
    • Immunology
    • Clinical Nutrition

    Background:

    • Food intolerance symptoms have diverse origins, including enzyme deficiencies (e.g., lactase), pharmacological reactions (e.g., caffeine), and irritable bowel syndrome.
    • Immunological mechanisms, though less common, are implicated in conditions like gluten enteropathy and childhood enteropathies linked to cow's milk.
    • Classical food allergy involves immediate reactions, often IgE-mediated, manifesting in gastrointestinal and extra-gastrointestinal symptoms like urticaria, asthma, and eczema.

    Purpose of the Study:

    • To review the various causes and diagnostic approaches for food intolerance.
    • To differentiate between true food allergy and pseudo-allergic reactions.
    • To highlight objective methods for detecting subclinical food intolerance reactions.

    Main Methods:

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    • Review of existing literature on food intolerance and allergy mechanisms.
    • Description of diagnostic strategies, including food elimination and blind challenges.
    • Discussion of objective detection methods, such as mediator response analysis.

    Main Results:

    • Food intolerance can result from enzyme deficiencies, pharmacological effects, or immunological responses.
    • Distinguishing between food allergy and pseudo-allergic reactions is crucial for accurate diagnosis.
    • Objective methods like mediator analysis aid in detecting subclinical intolerance.

    Conclusions:

    • Accurate diagnosis of food intolerance requires careful evaluation of symptoms, elimination diets, and objective testing.
    • Understanding the underlying mechanisms, whether enzymatic, pharmacological, or immunological, is key to managing food intolerance.
    • Blind challenges and mediator response detection offer objective confirmation of food intolerance.