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Updated: Jun 13, 2025

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Published on: April 9, 2018
Desulfonylative Functionalization of Organosulfones via Inert (Hetero)Aryl C(sp)-SO2 Bond Cleavage
Rui Huang1, Boning Gu2, Ming Wang2
1State Key Laboratory of Estuarine and Coastal Research, Hainan Institute of East China Normal University, East China Normal University, Shanghai 200241, China.
Abstract:
As "chemical chameleons," organosulfones have been widely applied in various desulfonylative functionalization reactions. However, the desulfonylative functionalization of (hetero)arylsulfones through the cleavage of inert C(sp)-SO2 bonds remains a challenging and underexplored task. Over the past twenty years, the use of (hetero)arylsulfones as arylation reagents has gradually gained attention in diverse cross-coupling reactions under specific catalytic conditions, especially in transition metal-catalysis and photocatalysis chemistry. In this review, we discuss the representative accomplishments and mechanistic insights achieved in desulfonylative reactions of inactive C(sp)-SO2 bonds in (hetero)arylsulfones, including: (i) transition-metal-catalyzed desulfonylative cross-coupling reactions and (ii) photo-/electrocatalytic radical desulfonylative coupling reactions. We anticipate that this review will provide an overall perspective in this area to a general audience of researchers and stimulate further innovative strategies for desulfonylative functionalization of inert arylsulfones.
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