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Tissue Engineering of the Intestine in a Murine Model

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Published on: December 1, 2012

Pediatric Chronic Intestinal Failure: Something Moving?

Aysenur Demirok¹, Sjoerd C J Nagelkerke¹, Marc A Benninga¹

¹Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

|September 14, 2024

Summary

Pediatric chronic intestinal failure (PIF) requires home parenteral nutrition (HPN) due to nutrient malabsorption. Advances improve outcomes, but research is needed for better nutritional, pharmacological, and surgical care.

Keywords:

catheter-related bloodstream infection catheter-related thrombosis central venous catheter congenital enteropathy home parenteral nutrition intestinal failure microvillus inclusion disease pediatric pediatric intestinal pseudo-obstruction short bowel syndrome

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Area of Science:

Pediatric gastroenterology and nutrition.

Background:

Pediatric chronic intestinal failure (PIF) is a rare condition where the intestine cannot absorb sufficient nutrients and fluids.
PIF necessitates home parenteral nutrition (HPN) for growth and homeostasis.
Underlying causes include short bowel syndrome, motility disorders, and congenital enteropathies.

Purpose of the Study:

To review the current understanding and management of pediatric chronic intestinal failure.
To highlight common complications associated with HPN and recent therapeutic advancements.

Main Methods:

A MEDLINE search was conducted in May 2024.
Keywords used were "intestinal failure", "parenteral nutrition", and "pediatric".

Main Results:

PIF encompasses various conditions requiring HPN, with common complications including infections, thrombosis, liver disease, bacterial overgrowth, bone disease, and renal impairment.
Treatment has improved, reducing morbidity and mortality.
Glucagon-like peptide 2 shows promise for short bowel syndrome.

Conclusions:

Centralization of care and international collaboration are crucial for improving outcomes in PIF.
Further research is essential for advancing nutritional, pharmacological, surgical, and preventative strategies in HPN.
Despite progress, optimizing care for pediatric patients with intestinal failure remains a priority.