Related Experiment Video

Updated: Jun 13, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.7K

The Relationship between Vitamin D, Inflammatory Markers, and Insulin Resistance in Children

Omer Okuyan1, Seyma Dumur2, Neval Elgormus3

  • 1Department of Pediatrics, Medicine Hospital, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Turkey.

Nutrients
|September 14, 2024
PubMed

Insights

Vitamin D deficiency in children is linked to higher inflammatory markers and insulin resistance (IR). Supplementing vitamin D may help reduce inflammation and prevent IR in pediatric populations.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Biochemistry
  • Immunology

Background:

  • Insulin resistance (IR) is a growing concern in pediatric populations, often associated with inflammation.
  • Hematologic inflammatory markers and vitamin D levels are increasingly recognized as potential contributors to metabolic dysfunction.

Purpose of the Study:

  • To investigate the relationship between 25-hydroxyvitamin D (25(OH)D) levels and inflammatory hematologic ratios (NLR, PLR, SII, MHR, PAI) with insulin resistance (IR) in children.
  • To explore the potential role of vitamin D in modulating systemic inflammation and insulin sensitivity.

Main Methods:

  • A cross-sectional study involving 210 children aged 6-18 years, categorized into groups with and without IR.
  • Analysis of vitamin D status, fasting insulin, HOMA-IR, HOMA-β, QUICKI, and inflammatory markers including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), monocyte/HDL-C ratio (MHR), and plasma atherogenic index (PAI).

Main Results:

  • Children with IR exhibited significantly higher NLR, PLR, SII, MHR, fasting insulin, PAI, HOMA-IR, and HOMA-β, along with lower QUICKI compared to controls.
  • Lower levels of NLR, SII, and MHR were observed in children with normal vitamin D levels.
  • PLR was significantly lower in children with normal vitamin D compared to those with insufficient or deficient levels.

Conclusions:

  • Childhood vitamin D deficiency is associated with elevated circulating inflammatory markers and impaired insulin sensitivity.
  • Vitamin D supplementation may offer a therapeutic strategy to mitigate IR and reduce systemic inflammation in children.
Abstract

Keywords:
childreninflammatory indexinsulin resistancemonocyte/HDL ratiovitamin D

More Related Videos

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

2.6K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

68.1K

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
157
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K