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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Protective Effects Of An Aged Black Garlic Water Extract On The Prostate

The Protective Effects of an Aged Black Garlic Water Extract on the Prostate

Maria Loreta Libero1,2,3, Antonio J Montero-Hidalgo2,3,4,5, Lucia Recinella1

  • 1Department of Pharmacy, "G. d'Annunzio" University, 66013 Chieti, Italy.

Nutrients
|September 14, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Aged black garlic extract (ABGE) shows anti-inflammatory and anti-cancer effects. It reduced inflammation markers in prostate tissue and inhibited prostate cancer cell growth and migration in lab studies.

Area of Science:

  • Oncology
  • Inflammation Research
  • Natural Product Chemistry

Background:

  • Chronic inflammation is a known risk factor for cancer development, including prostate cancer (PCa).
  • Prostate cancer (PCa) poses a significant health burden, necessitating novel therapeutic strategies.
  • Aged black garlic extract (ABGE) contains polyphenols like catechin and gallic acid, known for their bioactivity.

Purpose of the Study:

  • To investigate the anti-inflammatory effects of aged black garlic extract (ABGE) on inflammation-induced prostate damage.
  • To evaluate the therapeutic potential of ABGE against prostate cancer cell lines.
  • To explore the impact of ABGE on key inflammatory and cancer-related signaling pathways.

Main Methods:

  • Ex vivo model using C57BL/6 mouse prostate tissue treated with lipopolysaccharide (LPS) to induce inflammation.
Keywords:
ABGEcancerinflammationprostate

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  • Measurement of pro-inflammatory gene expression (COX-2, NF-κB, TNF-α, IL-6) in response to ABGE.
  • In vitro assays on prostate cancer cell lines assessing proliferation, colony formation, tumorsphere formation, and migration, with analysis of signaling pathways (MAPK, AKT, JAK/STAT, TGF-β).

    • Main Results:

    • ABGE demonstrated significant anti-inflammatory and antioxidant effects in preclinical models.
    • Ex vivo treatment with ABGE reduced the expression of key pro-inflammatory biomarkers (COX-2, NF-κB, TNF-α, IL-6).
    • In vitro studies showed ABGE inhibited prostate cancer cell proliferation, colony and tumorsphere formation, and migration.

    Conclusions:

    • Aged black garlic extract (ABGE) possesses notable anti-inflammatory and anti-cancer properties.
    • ABGE effectively mitigated inflammation-induced prostate damage in an ex vivo model.
    • ABGE shows therapeutic potential for managing prostate cancer by inhibiting cell growth and metastasis.