Progress on CRISPR-Cas gene editing technology in sheep production.

Area of Science:

• Molecular Biotechnology
• Genetics
• Animal Science

Background:

• Gene editing technologies allow for precise genome modification.
• The CRISPR-Cas system is a highly efficient and accurate gene editing tool.
• CRISPR-Cas has broad applications in livestock production.

Purpose of the Study:

• To review the mechanism and function of the CRISPR-Cas system.
• To summarize CRISPR-Cas applications in sheep production traits.
• To discuss the establishment of sheep animal models using CRISPR-Cas.

Main Methods:

• Review of scientific literature on CRISPR-Cas technology.
• Analysis of CRISPR-Cas applications in sheep genetics.
• Synthesis of data on gene editing for trait improvement in sheep.

Main Results:

• CRISPR-Cas enables site-specific genomic modifications (insertions, deletions, base replacements).
• Applications include enhancing reproductive, meat, wool, and lactation traits in sheep.
• CRISPR-Cas facilitates the creation of sheep models for disease resistance studies.

Conclusions:

• The CRISPR-Cas system is a valuable tool for advancing sheep production.
• Precise gene editing accelerates the improvement of economically important traits and disease resistance.
• CRISPR-Cas technology is crucial for developing improved sheep breeds and animal models.