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Association between fibrosis-4 index and cognitive impairment in elderly patients with hypertension: A

Hong Ding1, Jingtao Wang1, Shu Liu1

  • 1Department of Cardiovascular Medicine, Lanzhou University Second Hospital, Lanzhou, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|September 14, 2024
PubMed

Insights

A higher Fibrosis-4 index (FIB-4) is linked to cognitive decline in older adults with hypertension. This noninvasive marker may help identify individuals at risk for both liver disease and cognitive impairment.

Area of Science:

  • Gerontology
  • Neurology
  • Hepatology

Background:

  • The Fibrosis-4 index (FIB-4) is a validated noninvasive biomarker for hepatic fibrosis.
  • Hypertension is a prevalent comorbidity in older adults and a risk factor for cognitive decline.
  • The relationship between liver health markers and cognitive function in hypertensive individuals requires further investigation.

Purpose of the Study:

  • To investigate the association between the Fibrosis-4 index (FIB-4) and cognitive function decline in elderly hypertensive patients.
  • To explore the potential of FIB-4 as a predictor for cognitive impairment in this population.

Main Methods:

  • Cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
  • Analysis included 2039 participants aged 60 and older with hypertension.
  • Multivariate regression models and smoothed curve fitting were employed to assess the correlation between FIB-4 and cognitive performance metrics (CERAD Total Score, Animal Fluency, Digit Symbol).

Main Results:

  • A higher FIB-4 index was significantly associated with poorer cognitive function across multiple measures.
  • Statistically significant associations were observed for CERAD Total Score (OR=0.72), Animal Fluency Score (OR=0.66), and Digit Symbol Score (OR=0.36) in the fully adjusted model.
  • Nonlinear relationships were identified between FIB-4 and various cognitive scores, including CERAD Delayed Recall.

Conclusions:

  • Elevated FIB-4 index is correlated with an increased prevalence of cognitive decline in elderly hypertensive patients.
  • The FIB-4 index may serve as a valuable, noninvasive tool for identifying hypertensive individuals at risk for both liver-related complications and cognitive impairment.
  • Further research is warranted to elucidate the underlying mechanisms connecting hepatic fibrosis markers and neurocognitive health.

Keywords:
FIB‐4 indexcognitive functionhypertension

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