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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Jun 13, 2025

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
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Osteoporosis Management for Shoulder Surgeons.

Kelsey M Healy1, Jacob Ritter2, Emily Barr1

  • 1Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Winston-Salem, USA.

Current Reviews in Musculoskeletal Medicine
|September 14, 2024
PubMed
Summary

This review examines treating shoulder surgery in osteoporosis patients. Current evidence on perioperative osteoporosis medications shows no clear benefit, though animal studies suggest potential for bone healing.

Keywords:
ArthroplastyFractureOsteoporosisRotator CuffShoulderSurgery

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Area of Science:

  • Orthopedic Surgery
  • Bone Metabolism
  • Pharmacology

Background:

  • Osteoporosis significantly impacts bone quality, posing challenges for orthopedic procedures.
  • Surgical shoulder pathology in osteoporotic patients requires specialized management strategies.

Purpose of the Study:

  • To synthesize current literature on managing surgical shoulder pathology in patients with osteoporosis.
  • To evaluate the role of anti-osteoporosis medications in perioperative settings for shoulder surgery.

Main Methods:

  • Comprehensive literature review of studies on osteoporosis and shoulder surgery.
  • Analysis of clinical and pre-clinical data regarding perioperative medication use.
  • Assessment of surgical techniques and implant performance in osteopenic bone.

Main Results:

  • Clinical studies show inconclusive outcomes for perioperative anti-osteoporosis medications in shoulder surgery.
  • Pre-clinical animal studies indicate potential benefits of anabolic agents for tendon and bone healing.
  • Pre-operative optimization of bone health and risk factors remains crucial.

Conclusions:

  • Current clinical evidence does not support routine perioperative anti-osteoporosis medication use for shoulder surgery.
  • Further research is needed to validate the potential of anabolic agents as biologic augments in clinical settings.
  • Optimizing pre-operative bone health and employing suitable surgical techniques are key for successful outcomes.