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  11. The Effect Of Family History Of Atherosclerosıs And Other Risk Factors On Changes In Serum Lipid Levels In Acne Patients Treated With Isotretinoin.

The effect of family history of atherosclerosıs and other risk factors on changes in serum lipid levels in acne patients treated with isotretinoin.

Esra Rabia Akgüç1, Mine Müjde Kuş2

  • 1Department of Dermatology, Ankara Atatürk Sanatorium Training and Research Hospital, Ankara, 06290, Turkey.

Archives of Dermatological Research
|September 14, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Oral isotretinoin can alter serum lipid levels, particularly LDL, HDL, VLDL, total cholesterol, and triglycerides. Monitoring lipid values at baseline, 1 and 3 months is recommended, with more frequent checks for smokers, those with a family history of atherosclerosis, and individuals with a higher BMI.

Area of Science:

  • Dermatology
  • Clinical Chemistry
  • Pharmacology

Background:

  • Oral isotretinoin is known to affect serum lipid profiles in acne patients.
  • The specific causes and optimal monitoring frequency for these lipid changes remain unclear.
  • Individual variability in response to isotretinoin regarding lipid alterations exists.

Purpose of the Study:

  • To investigate the relationship between changes in serum lipid values and patient-specific or familial risk factors during oral isotretinoin therapy.
  • To identify factors that may predict or influence isotretinoin-induced dyslipidemia.

Main Methods:

  • A retrospective analysis of serum lipid levels (LDL, HDL, VLDL, total cholesterol, triglycerides) was conducted.
  • Data were collected from acne patients (aged 16+) treated with oral isotretinoin (0.5-1 mg/kg/day) between January 2017 and December 2019.
Keywords:
AcneAtherosclerosisBMIHyperlipidemia

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  • Statistical evaluation assessed the correlation between lipid changes and personal/familial risk factors.

    • Main Results:

    • Significant changes in all measured serum lipid levels were observed between baseline and 1, 3, and 6 months, but not between 3 and 6 months.
    • Elevated LDL and VLDL changes were noted in patients with a family history of atherosclerosis.
    • Increased BMI correlated with greater changes in total cholesterol and VLDL levels.
    • Smokers exhibited a more significant increase in VLDL levels compared to non-smokers.

    Conclusions:

    • Serum lipid monitoring at baseline, 1 month, and 3 months is recommended for all patients on oral isotretinoin.
    • Monthly lipid evaluations are advised for patients who smoke, have a history of atherosclerosis, or have a BMI above the normal range.
    • These recommendations aim to proactively manage potential isotretinoin-induced dyslipidemia.
    Isotretinoin
    Side effects
    Smoking